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The initial symptoms of MS are most often:

difficulty in walking;
abnormal sensations such as numbness or "pins and
needles"; and
pain and loss of vision due to optic neuritis, an
inflammation of the optic nerve.

Less common initial symptoms may include:

tremor;
incoordination;
slurred speech;
sudden onset of paralysis, similar to a stroke; and
a decline in cognitive function—the ability to think, reason,
and remember.

It is useful to divide the symptoms of MS into primary, secondary
and tertiary categories.

PRIMARY SYMPTOMS are a direct result of demyelination,
the destruction of myelin—the fatty sheath that surrounds and
insulates nerve fibers in the central nervous system. This impairs
transmission of nerve impulses to muscles and other organs. The
symptoms include weakness, numbness, tremor, loss of vision,
pain, paralysis, loss of balance, and bladder and bowel
dysfunction. Many of these symptoms can be managed effectively
with medication, rehabilitation, and other medically-based
methods.

SECONDARY SYMPTOMS are complications that arise as a
result of the primary symptoms. For example, bladder
dysfunction can cause repeated urinary tract infections. Inactivity
can result in disuse weakness (not related to demyelination),
poor postural alignment and trunk control, muscle imbalances
(adaptive shortening and/or stretch weakness), decreased bone
density (increasing risk of fracture), and shallow, inefficient
breathing. Paralysis can lead to the secondary symptom of
bedsores. While secondary symptoms can be treated, the optimal
goal is to avoid them by treating the primary symptoms.

TERTIARY SYMPTOMS are the social, vocational and
psychologic complications of the primary and secondary
symptoms. A person who becomes unable to walk or drive may
lose his or her livelihood. The strain of dealing with a chronic
neurologic illness may disrupt personal relationships. Depression
is frequently seen among people with MS. It may be a primary,
secondary, or tertiary symptom. Professional assistance from
psychologists, social workers, physical and occupational
therapists, and public health agencies is indicated for managing
many tertiary symptoms.

It is important to remember that many of the symptoms of MS
can be effectively managed, and complications avoided, with
regular care by a neurologist and allied health professionals.

RELATED TOPICS:

BLADDER DYSFUNCTION
BOWEL DYSFUNCTION
COGNITIVE FUNCTION
DEPRESSION
DIZZINESS AND VERTIGO
DYSPHAGIA
EMOTIONAL ASPECTS
FATIGUE
GAIT
HEADACHE
HEARING
ITCHING
NUMBNESS
PAIN
SEIZURES
SEXUALITY
SPASTICITY
SPEECH DISORDERS AND THERAPY
TREMOR
VISION
OPTIC NEURITIS
VISUAL SYMPTOMS
VISUAL LOSS

SOURCE: NMSS Information Resource Center and Library.
Compendium of Multiple Sclerosis Information (CMSI). ã
1997, National Multiple Sclerosis Society. Rev. 10/97

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